DARPP-32 and t-DARPP isoform in non-small cell lung cancer (NSCLC): could they drive patients' clinical management and be a therapeutic target?

Giuseppe Lamberti^{1

2}, Chiara Peterle^{1

2}, Francesco Gelsomino¹

Affiliations

¹ Medical Oncology Unit, Policlinico S.Orsola-Malpighi, Bologna, Italy.
² Department of Specialized, Experimental and Diagnostic Medicine, Policlinico S.Orsola-Malpighi, University of Bologna, Bologna, Italy.

Editorial

Giuseppe Lamberti et al. Transl Lung Cancer Res. 2018 Dec.

. 2018 Dec;7(Suppl 4):S326-S328.

doi: 10.21037/tlcr.2018.12.06.

Giuseppe Lamberti^{1

2}, Chiara Peterle^{1

2}, Francesco Gelsomino¹

¹ Medical Oncology Unit, Policlinico S.Orsola-Malpighi, Bologna, Italy.
² Department of Specialized, Experimental and Diagnostic Medicine, Policlinico S.Orsola-Malpighi, University of Bologna, Bologna, Italy.

No abstract available

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

DARPP-32 and t-DARPP promote non-small cell lung cancer growth through regulation of IKKα-dependent cell migration.
Alam SK, Astone M, Liu P, Hall SR, Coyle AM, Dankert EN, Hoffman DK, Zhang W, Kuang R, Roden AC, Mansfield AS, Hoeppner LH. Alam SK, et al. Commun Biol. 2018;1:43. doi: 10.1038/s42003-018-0050-6. Epub 2018 May 3. Commun Biol. 2018. PMID: 29782621 Free PMC article.

1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin 2018;68:7-30. 10.3322/caac.21442 - DOI - PubMed
1. Belkhiri A, Zhu S, El-Rifai W. DARPP-32: from neurotransmission to cancer. Oncotarget 2016;7:17631-40. 10.18632/oncotarget.7268 - DOI - PMC - PubMed
1. El-Rifai W, Smith MF, Jr, Li G, et al. Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPP. Cancer Res 2002;62:4061-4. - PubMed
1. Chen Z, Zhu S, Hong J, et al. Gastric tumour-derived ANGPT2 regulation by DARPP-32 promotes angiogenesis. Gut 2016;65:925-34. 10.1136/gutjnl-2014-308416 - DOI - PMC - PubMed
1. Wang MS, Pan Y, Liu N, et al. Overexpression of DARPP-32 in colorectal adenocarcinoma. Int J Clin Pract 2005;59:58-61. 10.1111/j.1742-1241.2004.00305.x - DOI - PubMed