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Case Reports
. 2019 Jan 11:14:74-76.
doi: 10.1016/j.ensci.2019.01.002. eCollection 2019 Mar.

Repetitive brainstem lesions in mitochondrial DNA 11778G>A mutation of Leber hereditary optic neuropathy

Noriyuki Miyaue  1   2 , Yuki Yamanishi  1 , Satoshi Tada  1 , Rina Ando  1 , Hayato Yabe  2 , Masahiro Nagai  1 , Masahiro Nomoto  1
Affiliations
Case Reports

Repetitive brainstem lesions in mitochondrial DNA 11778G>A mutation of Leber hereditary optic neuropathy

Noriyuki Miyaue et al. eNeurologicalSci. .

Abstract

•LHON cases can show brainstem lesions without visual impairment.•There can be inconsistency between MRI finding and clinical symptom in LHON cases.•Auditory pathways may be often involved in LHON cases.

Keywords: Brainstem lesions; Leber hereditary optic neuropathy; Leigh syndrome; Mitochondrial disorder.

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Figures

Fig. 1
Fig. 1
Brain MRI: (A) 19-year-old fluid attenuation inversion recovery (FLAIR) image showing bilateral hyperintensities of the inferior colliculus; (B) 21-year-old FLAIR image showing disappearance of the previous lesions of the inferior colliculus; (C) 24-year-old FLAIR image showing bilateral and symmetrical hyperintensities of vestibular nuclei.
See this image and copyright information in PMC

References

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