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Review
. 2018 Nov 7;3(6):e702.
doi: 10.1097/PR9.0000000000000702. eCollection 2018 Nov.

Rethinking the causes of pain in herpes zoster and postherpetic neuralgia: the ectopic pacemaker hypothesis

Marshall Devor  1
Affiliations
Review

Rethinking the causes of pain in herpes zoster and postherpetic neuralgia: the ectopic pacemaker hypothesis

Marshall Devor. Pain Rep. .

Abstract

Introduction: Pain in herpes zoster (HZ) and postherpetic neuralgia (PHN) is traditionally explained in terms of 2 processes: irritable nociceptors in the rash-inflamed skin and, later, deafferentation due to destruction of sensory neurons in one virally infected dorsal root ganglion.

Objectives and methods: Consideration of the evidence supporting this explanation in light of contemporary understanding of the pain system finds it wanting. An alternative hypothesis is proposed as a replacement.

Results: This model, the ectopic pacemaker hypothesis of HZ and PHN, proposes that pain in both conditions is driven by hyperexcitable ectopic pacemaker sites at various locations in primary sensory neurons affected by the causative varicella zoster virus infection. This peripheral input is exacerbated by central sensitization induced and maintained by the ectopic activity.

Conclusions: The shift in perspective regarding the pain mechanism in HZ/PHN has specific implications for clinical management.

Keywords: Deafferentation; Dorsal root ganglion; Dying-back; Ectopic discharge; Herpes zoster; Pain mechanism; Postherpetic neuralgia.

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Conflict of interest statement

Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.

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