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. 2019 Jan 31;6(1):23.
doi: 10.3390/medicines6010023.

Assessment of Artemisinin Contents in Selected Artemisia Species from Tajikistan (Central Asia)

Sodik Numonov  1   2   3 , Farukh Sharopov  4   5   6 , Aminjon Salimov  7 , Parviz Sukhrobov  8 , Sunbula Atolikshoeva  9 , Ramazon Safarzoda  10 , Maidina Habasi  11   12 , Haji Akber Aisa  13
Affiliations

Assessment of Artemisinin Contents in Selected Artemisia Species from Tajikistan (Central Asia)

Sodik Numonov et al. Medicines (Basel). .

Abstract

Background: Central Asia is the center of origin and diversification of the Artemisia genus. The genus Artemisia is known to possess a rich phytochemical diversity. Artemisinin is the shining example of a phytochemical isolated from Artemisia annua, which is widely used in the treatment of malaria. There is great interest in the discovery of alternative sources of artemisinin in other Artemisia species. Methods: The hexane extracts of Artemisia plants were prepared with ultrasound-assisted extraction procedures. Silica gel was used as an adsorbent for the purification of Artemisia annua extract. High-performance liquid chromatography with ultraviolet detection was performed for the quantification of underivatized artemisinin from hexane extracts of plants. Results: Artemisinin was found in seven Artemisia species collected from Tajikistan. Content of artemisinin ranged between 0.07% and 0.45% based on dry mass of Artemisia species samples. Conclusions: The artemisinin contents were observed in seven Artemisia species. A. vachanica was found to be a novel plant source of artemisinin. Purification of A. annua hexane extract using silica gel as adsorbent resulted in enrichment of artemisinin.

Keywords: Artemisia species; Artemisia vachanica; HPLC-PAD; Tajikistan; artemisinin.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Artemisinin structure.
Figure 2
Figure 2
Linear calibration graph for the standard artemisinin.
Figure 3
Figure 3
Total components number and artemisinin content in A. annua extract before and after purification.
See this image and copyright information in PMC

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