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Review
. 2019 Mar;12(1):149-163.
doi: 10.1016/j.path.2018.10.006.

SWI/SNF Complex-Deficient Soft Tissue Neoplasms: A Pattern-Based Approach to Diagnosis and Differential Diagnosis

Abbas Agaimy  1
Affiliations
Review

SWI/SNF Complex-Deficient Soft Tissue Neoplasms: A Pattern-Based Approach to Diagnosis and Differential Diagnosis

Abbas Agaimy. Surg Pathol Clin. 2019 Mar.

Abstract

Loss of different components of the Switch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex has been increasingly recognized as a central molecular event driving the initiation and/or dedifferentiation of mostly lethal but histogenetically diverse neoplasms in different body organs. This review summarizes and discusses the morphologic and phenotypic diversity of primary soft tissue neoplasms characterized by SWI/SNF complex deficiency with an emphasis on convergent and divergent cytoarchitectural patterns.

Keywords: Epithelioid sarcoma; Extraskeletal myxoid chondrosarcoma; INI1; Myoepithelial carcinoma; Rhabdoid tumor; SMARCA4; SMARCB1; SWI/SNF complex; Undifferentiated pediatric sarcoma.

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