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Review
. 2019 Mar;39(1):15-29.
doi: 10.1016/j.cll.2018.10.011. Epub 2018 Dec 18.

Regulatory and Effector B Cells: A New Path Toward Biomarkers and Therapeutic Targets to Improve Transplant Outcomes?

Aravind Cherukuri  1 , Qing Ding  2 , Akhil Sharma  1 , Kanishka Mohib  2 , David M Rothstein  3
Affiliations
Review

Regulatory and Effector B Cells: A New Path Toward Biomarkers and Therapeutic Targets to Improve Transplant Outcomes?

Aravind Cherukuri et al. Clin Lab Med. 2019 Mar.

Abstract

B cells shape the alloimmune response through polarized subsets. These cells inhibit or promote immune responses by expressing suppressive or proinflammatory cytokines. Their summed activity dictates the influence of B cells on the alloimmune response. We review the evidence for regulatory B cells and effector B cells in mice and humans, discuss current limitations in their phenotypic identification, and discuss regulatory B cells as a signature for clinical renal allograft tolerance and predictive markers for allograft outcomes. We discuss the effects of therapeutic agents on regulatory B cells and potential approaches to augment their numbers as a therapeutic tool.

Keywords: Biomarker; Effector B cells; Human; IL-10; Mouse; Regulatory B cells; TNF-α; Transplant tolerance.

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