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Comment
. 2019 Feb 1;79(3):437-438.
doi: 10.1158/0008-5472.CAN-18-3806.

Epigenetic Drift in Colorectal Cancer-It's Probably Later Than You Think

Carmen Sapienza  1
Affiliations
Comment

Epigenetic Drift in Colorectal Cancer-It's Probably Later Than You Think

Carmen Sapienza. Cancer Res. .

Abstract

The analysis of age-related methylation changes in patients with colorectal cancer indicates that tumors have their origins earlier in life than previously suspected. The implication is that healthy lifestyle modifications designed to prevent colorectal cancer should be adopted early in life.See related article by Luebeck et al., p. 495.

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  • Implications of Epigenetic Drift in Colorectal Neoplasia.
    Luebeck GE, Hazelton WD, Curtius K, Maden SK, Yu M, Carter KT, Burke W, Lampe PD, Li CI, Ulrich CM, Newcomb PA, Westerhoff M, Kaz AM, Luo Y, Inadomi JM, Grady WM. Luebeck GE, et al. Cancer Res. 2019 Feb 1;79(3):495-504. doi: 10.1158/0008-5472.CAN-18-1682. Epub 2018 Oct 5. Cancer Res. 2019. PMID: 30291105 Free PMC article.

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