Impact of years of blindness on neural circuits underlying auditory spatial representation

Abstract

Early visual deprivation impacts negatively on spatial bisection abilities. Recently, an early (50-90 ms) ERP response, selective for sound position in space, has been observed in the visual cortex of sighted individuals during the spatial but not the temporal bisection task. Here, we clarify the role of vision on spatial bisection abilities and neural correlates by studying late blind individuals. Results highlight that a shorter period of blindness is linked to a stronger contralateral activation in the visual cortex and a better performance during the spatial bisection task. Contrarily, not lateralized visual activation and lower performance are observed in individuals with a longer period of blindness. To conclude, the amount of time spent without vision may gradually impact on neural circuits underlying the construction of spatial representations in late blind participants. These findings suggest a key relationship between visual deprivation and auditory spatial abilities in humans.

Keywords: Auditory space perception; Blindness; Cross-modal plasticity; ERP; Visual cortex.