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Practice Guideline
. 2019 Apr;38(2):485-521.
doi: 10.1016/j.clnu.2018.12.022. Epub 2019 Jan 16.

ESPEN guideline on clinical nutrition in liver disease

Mathias Plauth  1 , William Bernal  2 , Srinivasan Dasarathy  3 , Manuela Merli  4 , Lindsay D Plank  5 , Tatjana Schütz  6 , Stephan C Bischoff  7
Affiliations
Practice Guideline

ESPEN guideline on clinical nutrition in liver disease

Mathias Plauth et al. Clin Nutr. 2019 Apr.

Abstract

This update of evidence-based guidelines (GL) aims to translate current evidence and expert opinion into recommendations for multidisciplinary teams responsible for the optimal nutritional and metabolic management of adult patients with liver disease. The GL was commissioned and financially supported by ESPEN. Members of the guideline group were selected by ESPEN. We searched for meta-analyses, systematic reviews and single clinical trials based on clinical questions according to the PICO format. The evidence was evaluated and used to develop clinical recommendations implementing the SIGN method. A total of 85 recommendations were made for the nutritional and metabolic management of patients with acute liver failure, severe alcoholic steatohepatitis, non-alcoholic fatty liver disease, liver cirrhosis, liver surgery and transplantation as well as nutrition associated liver injury distinct from fatty liver disease. The recommendations are preceded by statements covering current knowledge of the underlying pathophysiology and pathobiochemistry as well as pertinent methods for the assessment of nutritional status and body composition.

Keywords: Acute liver failure; Alcoholic steatohepatitis; Cirrhosis; Fatty liver disease; Sarcopenia; Transplantation.

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Conflict of interest statement

Conflict of interest

The expert members of the working group were accredited by the ESPEN Guidelines Group, the ESPEN Education and Clinical Practice Committee, and the ESPEN executive. All expert members have declared their individual conflicts of interest according to the rules of the International Committee of Medical Journal Editors (ICMJE). If potential conflicts were indicated, they were reviewed by the ESPEN guideline officers and, in cases of doubts, by the ESPEN executive. None of the expert panel had to be excluded from the working group or from co-authorship because of serious conflicts. The conflict of interest forms are stored at the ESPEN guideline office and can be reviewed by ESPEN members with legitimate interest upon request to the ESPEN executive.

Comment in

References

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