Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 May;53(5):674-677.
doi: 10.1016/j.ijantimicag.2019.01.013. Epub 2019 Feb 1.

Breakpoint to MIC quotient: A parameter to rapidly evaluate the in vitro bactericidal activity of β-lactams on Enterobacteriaceae

Antoine Grillon  1 , Angeline Chabaud  2 , Gilles Zambardi  3 , Isabelle Caniaux  4 , François Jehl  2
Affiliations

Breakpoint to MIC quotient: A parameter to rapidly evaluate the in vitro bactericidal activity of β-lactams on Enterobacteriaceae

Antoine Grillon et al. Int J Antimicrob Agents. 2019 May.

Abstract

Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) do not completely predict the bactericidal nature of the antimicrobial agent. Patients with pathogens having MICs near the clinical breakpoint experience a higher risk of clinical failure. This study defined an indicator, breakpoint to MIC quotient (BMQ), that incorporates MIC and the European Committee on Antimicrobial Susceptibility Testing breakpoint. The BMQ was inversely correlated with MBC in antibiotic combinations against Enterobacteriaceae strains (Spearman coefficient ≤ -0.96). This new parameter may provide timely additional insight for choosing an antibiotic for a severe bacterial infection.

Keywords: Breakpoint to MIC quotient; Enterobacteriaceae; Etest; European Committee on Antimicrobial Susceptibility Testing; Minimum Bactericidal Concentration; Minimum Inhibitory Concentration.

PubMed Disclaimer

MeSH terms

LinkOut - more resources