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Review
. 2019 Feb 3;8(2):179.
doi: 10.3390/jcm8020179.

Peptic Ulcer Disease: A Brief Review of Conventional Therapy and Herbal Treatment Options

Lucija Kuna  1 , Jelena Jakab  2   3 , Robert Smolic  4   5   6 , Nikola Raguz-Lucic  7 , Aleksandar Vcev  8   9 , Martina Smolic  10   11
Affiliations
Review

Peptic Ulcer Disease: A Brief Review of Conventional Therapy and Herbal Treatment Options

Lucija Kuna et al. J Clin Med. .

Abstract

Peptic ulcer is a chronic disease affecting up to 10% of the world's population. The formation of peptic ulcers depends on the presence of gastric juice pH and the decrease in mucosal defenses. Non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori (H. pylori) infection are the two major factors disrupting the mucosal resistance to injury. Conventional treatments of peptic ulcers, such as proton pump inhibitors (PPIs) and histamine-2 (H2) receptor antagonists, have demonstrated adverse effects, relapses, and various drug interactions. On the other hand, medicinal plants and their chemical compounds are useful in the prevention and treatment of numerous diseases. Hence, this review presents common medicinal plants that may be used for the treatment or prevention of peptic ulcers.

Keywords: Helicobacter pylori infection; herbal treatment; peptic ulcer disease.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
Schematic presentation of main pathophysiological mechanisms involved in the development of peptic ulcer disease, and the sites of action of the most commonly used pharmacological options in the treatment of peptic ulcer disease. CCK2 = Cholecystokinin Receptor; PGE2 = Prostaglandin E2; PGI2 = Prostaglandin I2; EP3 = Prostaglandin E receptor 3; HIST = Histamine.
See this image and copyright information in PMC

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