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. 1988 Nov 22;94(1-2):88-92.
doi: 10.1016/0304-3940(88)90275-3.

Changes in voltage dependence of NMDA currents during development

Y Ben-Ari  1 , E Cherubini, K Krnjevic
Affiliations

Changes in voltage dependence of NMDA currents during development

Y Ben-Ari et al. Neurosci Lett. .

Abstract

N-Methyl-D-aspartate (NMDA), applied by superfusion to hippocampal slices evokes comparable peak inward currents in CA3 pyramidal cells of adult and 0-10 day-old rats. However, NMDA current-voltage plots from immature neurones do not consistently show the region of negative slope conductance characteristic of adult. Therefore at a critical stage of development, NMDA activation may elicit substantial inward currents and Ca2+ influx at resting membrane potential.

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