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Review
. 2019 Mar;48(1):269-284.
doi: 10.1016/j.ecl.2018.10.010.

Diagnosis and Management of Anaplastic Thyroid Cancer

Ashish V Chintakuntlawar  1 , Robert L Foote  2 , Jan L Kasperbauer  3 , Keith C Bible  4
Affiliations
Review

Diagnosis and Management of Anaplastic Thyroid Cancer

Ashish V Chintakuntlawar et al. Endocrinol Metab Clin North Am. 2019 Mar.

Abstract

Anaplastic thyroid cancer (ATC) is a devastating and usually incurable diagnosis. Clinical and pathologic diagnosis is best assessed at a tertiary center with concentrated ATC expertise. Expeditious multidisciplinary management is recommended for optimal patient outcomes. Based on multiinstitutional and population-based studies, multimodal therapy that includes chemoradiotherapy with surgery (when feasible) is the preferred initial treatment because it is associated with incrementally improved overall survival. In ATC that carries a BRAF V600E somatic mutation, combination therapy with BRAF and MEK inhibitors has shown promise but needs further study. Immunotherapeutic agents in neoadjuvant and metastatic settings are being investigated.

Keywords: Anaplastic thyroid cancer; Chemoradiotherapy; Multimodality therapy; Systemic therapy.

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