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Meta-Analysis
. 2019 Feb 15;39(2):BSR20181901.
doi: 10.1042/BSR20181901. Print 2019 Feb 28.

The relationship between Fas and Fas ligand gene polymorphism and preeclampsia risk

Tingting Wang  1 , Yunyun Lian  2
Affiliations
Meta-Analysis

The relationship between Fas and Fas ligand gene polymorphism and preeclampsia risk

Tingting Wang et al. Biosci Rep. .

Abstract

Preeclampsia is an idiopathic multisystem disorder with partial genetic and immunological etiology. Several studies investigated the association between various single-nucleotide polymorphisms (SNPs) in Fas and Fas ligand (FasL) genes and the risk of preeclampsia. However, they achieved inconsistent results. Therefore, we conducted a meta-analysis by systematically searching the Cochrane Library, PubMed and Embase databases and assessed this association by calculating pooled odds ratios with 95% confidence interval to reach a more trustworthy conclusion. Subgroup analyses by genotype methods and source of controls (SOC) were also conducted. Seven citations containing nine studies were included for four SNPs (Fas -670 A/G, FasL 124A/G, FasL -844C/T, Fas -1377 G/A) in this meta-analysis. Our data suggested the G allele and genotype GG of the Fas -670 A/G polymorphism, GG genotype of the FasL 124A/G polymorphism, and TT genotype of the FasL -844C/T polymorphism increased the risk of preeclampsia. Stratification analyses by genotype methods and SOC also indicated that Fas -670 A/G polymorphism was related to increased risk for preeclampsia. In conclusion, Fas and FasL gene polymorphisms play important roles in the development of preeclampsia. Further well-designed studies in other races are needed to confirm the findings of this meta-analysis.

Keywords: Fas; FasL; meta-analysis; preeclampsia.

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Conflict of interest statement

The authors declare that there are no competing interests associated with the manuscript.

Figures

Figure 1
Figure 1. Selection for eligible papers included in this meta-analysis
Figure 2
Figure 2. Forest plot shows odds ratio for the association between Fas -670 A/G polymorphism and preeclampsia risk (G vs. A)
Figure 3
Figure 3. Forest plot shows odds ratio for the association between Fas -670 A/G polymorphism and preeclampsia risk (GG+AG vs. AA)
See this image and copyright information in PMC

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