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Review
. 2018 May-Jun;9(4):381-386.
Epub 2018 May 1.

Feasibility of Outpatient High-Dose Methotrexate Infusions in Pediatric Patients With B-Lineage Acute Lymphoblastic Leukemia

Joy L Bartholomew  1 , Hongying Dai  1 , Keith J August  1 , Robin E Ryan  1 , Kristin A Stegenga  1
Affiliations
Review

Feasibility of Outpatient High-Dose Methotrexate Infusions in Pediatric Patients With B-Lineage Acute Lymphoblastic Leukemia

Joy L Bartholomew et al. J Adv Pract Oncol. 2018 May-Jun.

Abstract

High-dose methotrexate (MTX) given in four hospitalizations during interim maintenance for high-risk pediatric B-lineage acute lymphocytic leukemia significantly improves survival but increases resource utilization. Children remain hospitalized for intravenous hydration and blood or urine monitoring until MTX clearance parameters are reached. Improved supportive care, extended infusion center hours, and pediatric home health expertise afford alternatives to prolonged hospital admissions, potentially offering quality, cost-effective approaches that positively impact the delivery of care.

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Figures

Figure 1
Figure 1
Study design.
Figure 2
Figure 2
Paired profiles for antiemetic use.
Table 1
Table 1
Inpatient Compared to Outpatient Infusions
See this image and copyright information in PMC

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