Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Dec 5;8(6):e83128.
doi: 10.5812/aapm.83128. eCollection 2018 Dec.

Flow Cytometry of CD64, HLA-DR, CD25, and TLRs for Diagnosis and Prognosis of Sepsis in Critically Ill Patients Admitted to the Intensive Care Unit: A Review Article

Ata Mahmoodpoor  1 , Seyedpouya Paknezhad  2 , Kamran Shadvar  1 , Hadi Hamishehkar  3 , Ali Akbar Movassaghpour  4 , Sarvin Sanaie  5 , Ali Akbar Ghamari  1 , Hassan Soleimanpour  2
Affiliations
Review

Flow Cytometry of CD64, HLA-DR, CD25, and TLRs for Diagnosis and Prognosis of Sepsis in Critically Ill Patients Admitted to the Intensive Care Unit: A Review Article

Ata Mahmoodpoor et al. Anesth Pain Med. .

Abstract

Sepsis is an important health problem with a high burden on health systems. Finding new aspects of immune system function in sepsis showed a new role for flow cytometry in the diagnosis of sepsis. We made a review on the role of CD64, HLA-DR, CD25, and TLRs as more useful flow cytometric tools in diagnosing sepsis, both in adults, and neonates. According to our results, we concluded that for diagnosis and treatment of the septic, flow cytometry can play an important role so that it can be used as a novel method in individualized treatment of septic patients based on their immune system situation.

Keywords: CD 25; CD 64; Flow Cytometry; HLA-DR; Sepsis; Toll Like Receptor.

PubMed Disclaimer

References

    1. Monneret G, Venet F, Pachot A, Lepape A. Monitoring immune dysfunctions in the septic patient: A new skin for the old ceremony. Mol Med. 2008;14(1-2):64–78. doi: 10.2119/2007-00102.Monneret. - DOI - PMC - PubMed
    1. Warren HS. Strategies for the treatment of sepsis. N Engl J Med. 1997;336(13):952–3. doi: 10.1056/NEJM199703273361311. - DOI - PubMed
    1. Brunkhorst FM. [Epidemiology, economy and practice - results of the German study on prevalence by the competence network sepsis (SepNet).]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2006;41(1):43–4. doi: 10.1055/s-2005-921227. (Ger). - DOI - PubMed
    1. Scerbo MH, Kaplan HB, Dua A, Litwin DB, Ambrose CG, Moore LJ, et al. Beyond blood culture and gram stain analysis: A review of molecular techniques for the early detection of bacteremia in surgical patients. Surg Infect (Larchmt). 2016;17(3):294–302. doi: 10.1089/sur.2015.099. - DOI - PMC - PubMed
    1. Liu Y, Hou JH, Li Q, Chen KJ, Wang SN, Wang JM. Biomarkers for diagnosis of sepsis in patients with systemic inflammatory response syndrome: A systematic review and meta-analysis. Springerplus. 2016;5(1):2091. doi: 10.1186/s40064-016-3591-5. - DOI - PMC - PubMed

LinkOut - more resources