Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1988 Dec;26(6):741-6.
doi: 10.1111/j.1365-2125.1988.tb05313.x.

Comparison of the effect of cisapride and metoclopramide on morphine-induced delay in gastric emptying

D J Rowbotham  1 , P A Bamber, W S Nimmo
Affiliations
Clinical Trial

Comparison of the effect of cisapride and metoclopramide on morphine-induced delay in gastric emptying

D J Rowbotham et al. Br J Clin Pharmacol. 1988 Dec.

Abstract

1. The effects of metoclopramide or cisapride on morphine-induced delay in gastric emptying in patients before surgery were compared. 2. Forty patients were allocated randomly to receive one of four premedications i.m.: placebo only, morphine 10 mg alone, morphine 10 mg with metoclopramide 10 mg and morphine 10 mg with cisapride 10 mg. Gastric emptying after each premedication was assessed indirectly from the rate of absorption of oral paracetamol. 3. Cisapride 10 mg reversed the delay in gastric emptying due to morphine. Its effects were significantly greater than those of metoclopramide 10 mg.

PubMed Disclaimer

References

    1. Br Med J. 1973 Feb 24;1(5851):446-8 - PubMed
    1. Lancet. 1975 Apr 19;1(7912):890-3 - PubMed
    1. Br J Clin Pharmacol. 1975 Dec;2(6):509-13 - PubMed
    1. J Pharm Pharmacol. 1977 Apr;29(4):235-7 - PubMed
    1. Acta Anaesthesiol Scand. 1982 Oct;26(5):417-20 - PubMed

LinkOut - more resources