Review
doi: 10.1016/0378-1119(88)90492-1.
Conserved sequences and structures of group I introns: building an active site for RNA catalysis--a review
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- PMID: 3072259
- DOI: 10.1016/0378-1119(88)90492-1
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Review
Conserved sequences and structures of group I introns: building an active site for RNA catalysis--a review
Gene.
.
Abstract
Group I introns fold to form an active site to mediate their own RNA splicing. Sequence elements conserved among the available set of 66 group I introns are compiled. Comparative sequence analysis leads to the prediction of some conserved structural features that have not been widely appreciated. The possible significance of conserved nucleotides within base-paired duplexes is discussed; they might be involved in base triplets or alternate pairing interactions.
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