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Comment
. 2019 Mar;9(3):314.
doi: 10.1158/2159-8290.CD-NB2019-012. Epub 2019 Feb 5.

Hypoxic Tumors Share Genomic Instability

No authors listed
Comment

Hypoxic Tumors Share Genomic Instability

No authors listed. Cancer Discov. 2019 Mar.

Abstract

A genomic analysis of 8,006 tumors spanning 19 cancer types suggests that hypoxic tumors share common features, including genomic instability. Eleven types of cancer carried extra copies of MYC, and seven types had lost PTEN. The study also found that miRNA dysregulation was prevalent across tumor types.

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  • Molecular landmarks of tumor hypoxia across cancer types.
    Bhandari V, Hoey C, Liu LY, Lalonde E, Ray J, Livingstone J, Lesurf R, Shiah YJ, Vujcic T, Huang X, Espiritu SMG, Heisler LE, Yousif F, Huang V, Yamaguchi TN, Yao CQ, Sabelnykova VY, Fraser M, Chua MLK, van der Kwast T, Liu SK, Boutros PC, Bristow RG. Bhandari V, et al. Nat Genet. 2019 Feb;51(2):308-318. doi: 10.1038/s41588-018-0318-2. Epub 2019 Jan 14. Nat Genet. 2019. PMID: 30643250

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