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. 2019 Jan 6:2019:2069701.
doi: 10.1155/2019/2069701. eCollection 2019.

Natural Killer Response and Lipo-Metabolic Profile in Adults with Low HDL-Cholesterol and Mild Hypercholesterolemia: Beneficial Effects of Artichoke Leaf Extract Supplementation

M Rondanelli  1   2 , A M Castellazzi  3 , A Riva  4 , P Allegrini  4 , M A Faliva  5 , G Peroni  5 , M Naso  5 , M Nichetti  5 , C Tagliacarne  3 , C Valsecchi  3 , T Fazia  6 , S Perna  7 , F Graziano  6 , M Grassi  6 , L Bernardinelli  6
Affiliations

Natural Killer Response and Lipo-Metabolic Profile in Adults with Low HDL-Cholesterol and Mild Hypercholesterolemia: Beneficial Effects of Artichoke Leaf Extract Supplementation

M Rondanelli et al. Evid Based Complement Alternat Med. .

Abstract

The aim of the present study is to evaluate the effects of 60-day artichoke leaf extract (ALE) supplementation (250mg, twice daily) on cytokines levels, natural killer cell (NK) response, and lipo-metabolic profile (HDL, LDL, and total-cholesterol, triglycerides (TG), ApoB, ApoA, lipid accumulation product (LAP), glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR)) in twenty adults (9/11 males/females, age=49.10 ± 13.74 years, and BMI=33.12 ± 5.14 kg/m2) with low HDL-C and mild hypercholesterolemia. Hierarchical generalized linear model, adjusted for sex, BMI, and age, has been used to evaluate pre-post treatment changes. A significant increase for HDL-C (β=0.14, p=0.0008) and MCP-1 (β=144.77, p=0.004) and a significant decrease for ApoB/ApoA (β=-0.07, p=0.03), total-C/HDL-C ratio (β=-0.58, p<0.001), and NK response at stimulus low (β=0.43, p=0.04), medium (β=0.40, p<0.001), and high (β=0.42, p=0.001) have been found. These results support the benefits of ALE supplementation on metabolic profile.

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Figures

Figure 1
Figure 1
Pre- and posttreatment means.
Figure 2
Figure 2
Partial correlation, adjusted for sex and age, between HDL-C and each secondary endpoint before and after treatment.
See this image and copyright information in PMC

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