Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1988 Jan;5(1):1-9.
doi: 10.1023/a:1015860525341.

Monoclonal antibodies as magic bullets

F M Brodsky  1
Affiliations
Review

Monoclonal antibodies as magic bullets

F M Brodsky. Pharm Res. 1988 Jan.

Abstract

Monoclonal antibodies have been used as experimental therapy in humans since the beginning of the 1980s (A.N. Houghton and D. A. Scheinberg. Semin. Oncol. 13:165-179, 1986). They have been hailed as the prototypical magic bullet drug because of their inherent capacity for specificity. Consequently, monoclonal antibodies have many possible therapeutic applications with varied potential for successful outcome. Current review articles discussing monoclonal antibody therapy deal with the application of monoclonal antibodies within specific areas of medicine. The aim of this review is to summarize the current reviews and provide a broader perspective on the medical applications of monoclonal antibodies along with some general principles by which their therapeutic success or failure might be understood.

PubMed Disclaimer

References

    1. Annu Rev Biochem. 1981;50:85-101 - PubMed
    1. Annu Rev Immunol. 1983;1:87-117 - PubMed
    1. Science. 1985 Aug 23;229(4715):765-7 - PubMed
    1. J Am Coll Cardiol. 1985 May;5(5 Suppl A):118A-123A - PubMed
    1. West J Med. 1985 Dec;143(6):804-9 - PubMed

Publication types

Substances

LinkOut - more resources