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Review
. 1988 Mar;5(3):129-39.
doi: 10.1023/a:1015904721223.

The role of tumor necrosis factor and interleukin 1 in the immunoinflammatory response

J W Larrick  1 , S L Kunkel
Affiliations
Free article
Review

The role of tumor necrosis factor and interleukin 1 in the immunoinflammatory response

J W Larrick et al. Pharm Res. 1988 Mar.
Free article

Abstract

Monocytes and tissue macrophages produce at least two groups of protein mediators of inflammation, interleukin 1 (IL-1) and tumor necrosis factor (TNF). Recent studies have emphasized that TNF and IL-1 modulate the inflammatory function of endothelial cells, leukocytes, and fibroblasts. Although these cytokines share a number of biologic properties, they have quite distinct gene and protein structures. It is our purpose to focus on the role of these mediators in inflammation.

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