Free radicals and oxygen toxicity

Abstract

Most organisms are constantly exposed to molecular oxygen, and this has become a requirement of life for many of them. Oxygen is not totally innocuous, however, and it has long been known to be toxic to many organisms, including humans. The deleterious effects of oxygen are thought to result from its metabolic reduction to highly reactive and toxic species, including superoxide anion radical and hydroxyl radical. Peroxidation of lipids is a major consequence of exposure to these species and the cell possesses various enzymes, including superoxide dismutase and catalase, as well as cellular antioxidants which are able to scavenge oxygen free radicals and repair peroxidized lipids. These aspects of oxygen toxicity are reviewed, as well as the involvement of oxygen free radicals in the toxicity of the herbicide paraquat.