Paclitaxel
- PMID: 30725602
- Bookshelf ID: NBK536917
Paclitaxel
Excerpt
The field of oncology is in a constant state of evolution and is driven by ongoing research discoveries and advancements in treatment approaches. Paclitaxel belongs to the category of chemotherapeutic agents and is utilized as a treatment for various types of cancer. Indications for using paclitaxel encompass a range of cancers, including breast, ovarian, bladder, lung, prostate, melanoma, esophageal, Kaposi sarcoma, and various other solid tumors. This therapeutic review provides an overview of paclitaxel's indications, mechanisms of action at the cellular level, role in inhibiting cancer cell growth, essential information on dosing regimens, infusion protocols, methods of administration, and contraindications, as well as the importance of monitoring patients undergoing paclitaxel therapy.
Copyright © 2025, StatPearls Publishing LLC.
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References
-
- McGuire WP, Hoskins WJ, Brady MF, Kucera PR, Partridge EE, Look KY, Clarke-Pearson DL, Davidson M. Comparison of combination therapy with paclitaxel and cisplatin versus cyclophosphamide and cisplatin in patients with suboptimal stage III and stage IV ovarian cancer: a Gynecologic Oncology Group study. Semin Oncol. 1997 Feb;24(1 Suppl 2):S2-13-S2-16. - PubMed
-
- Armstrong DK, Bundy B, Wenzel L, Huang HQ, Baergen R, Lele S, Copeland LJ, Walker JL, Burger RA, Gynecologic Oncology Group Intraperitoneal cisplatin and paclitaxel in ovarian cancer. N Engl J Med. 2006 Jan 05;354(1):34-43. - PubMed
-
- Nardi M, Aloe A, De Marco S, Cognetti F, Iacovelli A, Atlante G, Calabresi F. Paclitaxel as salvage therapy in advanced pretreated ovarian cancer: a phase II study. Am J Clin Oncol. 1997 Jun;20(3):230-2. - PubMed
-
- Mayerhofer K, Kucera E, Zeisler H, Speiser P, Reinthaller A, Sevelda P. Taxol as second-line treatment in patients with advanced ovarian cancer after platinum-based first-line chemotherapy. Gynecol Oncol. 1997 Jan;64(1):109-13. - PubMed
-
- Loesch D, Greco FA, Senzer NN, Burris HA, Hainsworth JD, Jones S, Vukelja SJ, Sandbach J, Holmes F, Sedlacek S, Pippen J, Lindquist D, McIntyre K, Blum JL, Modiano MR, Boehm KA, Zhan F, Asmar L, Robert N. Phase III multicenter trial of doxorubicin plus cyclophosphamide followed by paclitaxel compared with doxorubicin plus paclitaxel followed by weekly paclitaxel as adjuvant therapy for women with high-risk breast cancer. J Clin Oncol. 2010 Jun 20;28(18):2958-65. - PubMed
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