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Book

Lactulose

Samiran Mukherjee  1 , Preeti Patel, Savio John  1
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
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Book

Lactulose

Samiran Mukherjee et al.
Free Books & Documents

Excerpt

Lactulose is a versatile pharmaceutical agent helpful in preventing and treating clinical portal-systemic encephalopathy. By primarily targeting the reduction of intestinal production and absorption of ammonia, this drug addresses the root cause of the condition. Beyond its established efficacy in portal-systemic encephalopathy, lactulose has garnered recognition as a potential therapeutic solution for subacute clinical encephalopathy.

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Conflict of interest statement

Disclosure: Samiran Mukherjee declares no relevant financial relationships with ineligible companies.

Disclosure: Preeti Patel declares no relevant financial relationships with ineligible companies.

Disclosure: Savio John declares no relevant financial relationships with ineligible companies.

References

    1. Haemmerli UP, Bircher J. Wrong idea, good results (the lactulose story). N Engl J Med. 1969 Aug 21;281(8):441-2. - PubMed
    1. Dhiman RK, Sawhney MS, Chawla YK, Das G, Ram S, Dilawari JB. Efficacy of lactulose in cirrhotic patients with subclinical hepatic encephalopathy. Dig Dis Sci. 2000 Aug;45(8):1549-52. - PubMed
    1. Wesselius-De Casparis A, Braadbaart S, Bergh-Bohlken GE, Mimica M. Treatment of chronic constipation with lactulose syrup: results of a double-blind study. Gut. 1968 Feb;9(1):84-6. - PMC - PubMed
    1. Portalatin M, Winstead N. Medical management of constipation. Clin Colon Rectal Surg. 2012 Mar;25(1):12-9. - PMC - PubMed
    1. VanBerge-Henegouwen GP, Portincasa P, van Erpecum KJ. Effect of lactulose and fiber-rich diets on bile in relation to gallstone disease: an update. Scand J Gastroenterol Suppl. 1997;222:68-71. - PubMed

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