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Book

Mantle Cell Lymphoma

David T. Lynch  1 , Supriya Koya  2 , Sindhuja Dogga  3 , Abhishek Kumar  4
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Mantle Cell Lymphoma

David T. Lynch et al.
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Excerpt

Mantle cell lymphoma (MCL) is a rare subtype of B-cell non-Hodgkin lymphomas (NHLs) characterized by an (11,14) translocation resulting in overexpression of the cyclin D1 (CCND1) gene. The variety of morphologic variants may make this a challenging diagnosis, although some cases are uncomplicated. It typically follows an aggressive clinical course (aggressive MCL), although an indolent leukemia variant (indolent MCL) has been described.

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Conflict of interest statement

Disclosure: David Lynch declares no relevant financial relationships with ineligible companies.

Disclosure: Supriya Koya declares no relevant financial relationships with ineligible companies.

Disclosure: Sindhuja Dogga declares no relevant financial relationships with ineligible companies.

Disclosure: Abhishek Kumar declares no relevant financial relationships with ineligible companies.

References

    1. Li S, Xu J, You MJ. The pathologic diagnosis of mantle cell lymphoma. Histol Histopathol. 2021 Oct;36(10):1037-1051. - PubMed
    1. Fu K, Weisenburger DD, Greiner TC, Dave S, Wright G, Rosenwald A, Chiorazzi M, Iqbal J, Gesk S, Siebert R, De Jong D, Jaffe ES, Wilson WH, Delabie J, Ott G, Dave BJ, Sanger WG, Smith LM, Rimsza L, Braziel RM, Müller-Hermelink HK, Campo E, Gascoyne RD, Staudt LM, Chan WC, Lymphoma/Leukemia Molecular Profiling Project Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling. Blood. 2005 Dec 15;106(13):4315-21. - PMC - PubMed
    1. Vegliante MC, Palomero J, Pérez-Galán P, Roué G, Castellano G, Navarro A, Clot G, Moros A, Suárez-Cisneros H, Beà S, Hernández L, Enjuanes A, Jares P, Villamor N, Colomer D, Martín-Subero JI, Campo E, Amador V. SOX11 regulates PAX5 expression and blocks terminal B-cell differentiation in aggressive mantle cell lymphoma. Blood. 2013 Mar 21;121(12):2175-85. - PubMed
    1. Navarro A, Beà S, Jares P, Campo E. Molecular Pathogenesis of Mantle Cell Lymphoma. Hematol Oncol Clin North Am. 2020 Oct;34(5):795-807. - PMC - PubMed
    1. Lynch DT, Foucar K. Discrete vacuoles in lymphocytes as a subtle clue to mantle cell lymphoma. Blood. 2016 Jun 23;127(25):3292. - PubMed

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