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Book

Meconium Ileus

Nirzar S. Parikh  1 , Sherif Y. Ibrahim, Rajni Ahlawat  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Meconium Ileus

Nirzar S. Parikh et al.
Free Books & Documents

Excerpt

In neonates, meconium Ileus (MI) is one of the earliest manifestations in patients with cystic fibrosis (CF). It presents in up to 20% of patients with CF. The inspissated meconium obstructs the small intestine at the level of the terminal ileum. If left untreated, the prognosis is poor.

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Conflict of interest statement

Disclosure: Nirzar Parikh declares no relevant financial relationships with ineligible companies.

Disclosure: Sherif Ibrahim declares no relevant financial relationships with ineligible companies.

Disclosure: Rajni Ahlawat declares no relevant financial relationships with ineligible companies.

References

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    1. Fakhoury K, Durie PR, Levison H, Canny GJ. Meconium ileus in the absence of cystic fibrosis. Arch Dis Child. 1992 Oct;67(10 Spec No):1204-6. - PMC - PubMed
    1. Gorter RR, Karimi A, Sleeboom C, Kneepkens CM, Heij HA. Clinical and genetic characteristics of meconium ileus in newborns with and without cystic fibrosis. J Pediatr Gastroenterol Nutr. 2010 May;50(5):569-72. - PubMed
    1. Dupuis A, Keenan K, Ooi CY, Dorfman R, Sontag MK, Naehrlich L, Castellani C, Strug LJ, Rommens JM, Gonska T. Prevalence of meconium ileus marks the severity of mutations of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. Genet Med. 2016 Apr;18(4):333-40. - PubMed
    1. ACOG Committee Opinion No. 486: Update on carrier screening for cystic fibrosis. Obstet Gynecol. 2011 Apr;117(4):1028-1031. - PubMed

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