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Book

Antiplatelet Medications

Arshad Muhammad Iqbal  1 , Richard A. Lopez  2 , Ofek Hai  3
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Antiplatelet Medications

Arshad Muhammad Iqbal et al.
Free Books & Documents

Excerpt

Over time, numerous antiplatelet agents have been developed with many indications. Antiplatelet medications divide into oral and parenteral agents, and oral agents subdivide further based on the mechanism of action. Aspirin was the first antiplatelet medication and is a cyclooxygenase inhibitor. Other oral antiplatelet include clopidogrel, ticagrelor, and prasugrel, cilostazol, and dipyridamole. Glycoprotein IIb/IIIa inhibitors such as tirofiban and eptifibatide are only available as parenteral agents and are used in acute phases of acute coronary syndrome. This activity reviews the indications, contraindications, actions, adverse events, and other key elements of antiplatelet drugs essential to clinical practice.

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Conflict of interest statement

Disclosure: Arshad Muhammad Iqbal declares no relevant financial relationships with ineligible companies.

Disclosure: Richard Lopez declares no relevant financial relationships with ineligible companies.

Disclosure: Ofek Hai declares no relevant financial relationships with ineligible companies.

References

    1. Eikelboom JW, Hirsh J, Spencer FA, Baglin TP, Weitz JI. Antiplatelet drugs: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012 Feb;141(2 Suppl):e89S-e119S. - PMC - PubMed
    1. Krötz F, Sohn HY, Klauss V. Antiplatelet drugs in cardiological practice: established strategies and new developments. Vasc Health Risk Manag. 2008;4(3):637-45. - PMC - PubMed
    1. Hashemzadeh M, Furukawa M, Goldsberry S, Movahed MR. Chemical structures and mode of action of intravenous glycoprotein IIb/IIIa receptor blockers: A review. Exp Clin Cardiol. 2008 Winter;13(4):192-7. - PMC - PubMed
    1. Warner TD, Nylander S, Whatling C. Anti-platelet therapy: cyclo-oxygenase inhibition and the use of aspirin with particular regard to dual anti-platelet therapy. Br J Clin Pharmacol. 2011 Oct;72(4):619-33. - PMC - PubMed
    1. Kubica J, Kozinski M, Navarese EP, Tantry U, Kubica A, Siller-Matula JM, Jeong YH, Fabiszak T, Andruszkiewicz A, Gurbel PA. Cangrelor: an emerging therapeutic option for patients with coronary artery disease. Curr Med Res Opin. 2014 May;30(5):813-28. - PubMed

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