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The chemoreceptor trigger zone (CTZ) for emesis, also commonly known as the area postrema (AP), is located within the dorsal surface of the medulla oblongata, on the floor of the fourth ventricle of the brain. The CTZ contains receptors that detect emetic agents in the blood and relays that information to the vomiting center, which is responsible for inducing the vomiting reflex.
Miller AD, Leslie RA. The area postrema and vomiting. Front Neuroendocrinol. 1994 Dec;15(4):301-20.
-
PubMed
Popescu BF, Lennon VA, Parisi JE, Howe CL, Weigand SD, Cabrera-Gómez JA, Newell K, Mandler RN, Pittock SJ, Weinshenker BG, Lucchinetti CF. Neuromyelitis optica unique area postrema lesions: nausea, vomiting, and pathogenic implications. Neurology. 2011 Apr 05;76(14):1229-37.
-
PMC
-
PubMed
Becker DE. Nausea, vomiting, and hiccups: a review of mechanisms and treatment. Anesth Prog. 2010 Winter;57(4):150-6; quiz 157.
-
PMC
-
PubMed
Bhargava KP, Dixit KS. Role of the chemoreceptor trigger zone in histamine-induced emesis. Br J Pharmacol. 1968 Nov;34(3):508-13.
-
PMC
-
PubMed
Bhargava KP, Dixit KS, Gupta YK. Enkephalin receptors in the emetic chemoreceptor trigger zone of the dog. Br J Pharmacol. 1981 Mar;72(3):471-5.
-
PMC
-
PubMed