Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Book

Physiology, Bradykinin

Yasaman Pirahanchi  1 , Sandeep Sharma  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
Affiliations
Free Books & Documents
Book

Physiology, Bradykinin

Yasaman Pirahanchi et al.
Free Books & Documents

Excerpt

Bradykinin is a molecule that plays a crucial role in inflammation. In this review, we will discuss the cellular basis of bradykinin production, function, pathophysiology, and clinical significance. Bradykinin can act as a vasoactive substance along with histamine in inflammation and swelling as it is a potent vasodilator. Bradykinin also plays a significant role in the pathophysiology of C1 esterase inhibitor deficiency and in the clinical application of considering whether to use angiotensin-converting enzyme inhibitors or angiotensin two receptor blockers.

PubMed Disclaimer

Conflict of interest statement

Disclosure: Yasaman Pirahanchi declares no relevant financial relationships with ineligible companies.

Disclosure: Sandeep Sharma declares no relevant financial relationships with ineligible companies.

References

    1. Hofman Z, de Maat S, Hack CE, Maas C. Bradykinin: Inflammatory Product of the Coagulation System. Clin Rev Allergy Immunol. 2016 Oct;51(2):152-61. - PMC - PubMed
    1. Qadri F, Bader M. Kinin B1 receptors as a therapeutic target for inflammation. Expert Opin Ther Targets. 2018 Jan;22(1):31-44. - PubMed
    1. Choi SI, Hwang SW. Depolarizing Effectors of Bradykinin Signaling in Nociceptor Excitation in Pain Perception. Biomol Ther (Seoul) 2018 May 01;26(3):255-267. - PMC - PubMed
    1. Grumach AS, Ferraroni N, Olivares MM, López-Serrano MC, Bygum A. An ABC of the Warning Signs of Hereditary Angioedema. Int Arch Allergy Immunol. 2017;174(1):1-6. - PubMed
    1. Farkas H. Pharmacological Management of Hereditary Angioedema with C1-Inhibitor Deficiency in Pediatric Patients. Paediatr Drugs. 2018 Apr;20(2):135-151. - PubMed

Publication types

LinkOut - more resources