Norepinephrine
- PMID: 30725944
- Bookshelf ID: NBK537259
Norepinephrine
Excerpt
Untreated hypotension is a significant contributor to morbidity and mortality, requiring prompt and effective management. Norepinephrine is a first-line pharmacological agent for hypotension unresponsive to fluid therapy. Understanding norepinephrine's pharmacokinetics, pharmacodynamics, and clinical application is essential for optimizing outcomes in critically ill patients. To ensure safe administration, healthcare professionals must also understand norepinephrine's indications, contraindications, dosing strategies, and adverse drug reaction profile.
Copyright © 2025, StatPearls Publishing LLC.
Conflict of interest statement
Sections
References
-
- Russell JA. Vasopressor therapy in critically ill patients with shock. Intensive Care Med. 2019 Nov;45(11):1503-1517. - PubMed
-
- Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, Kumar A, Sevransky JE, Sprung CL, Nunnally ME, Rochwerg B, Rubenfeld GD, Angus DC, Annane D, Beale RJ, Bellinghan GJ, Bernard GR, Chiche JD, Coopersmith C, De Backer DP, French CJ, Fujishima S, Gerlach H, Hidalgo JL, Hollenberg SM, Jones AE, Karnad DR, Kleinpell RM, Koh Y, Lisboa TC, Machado FR, Marini JJ, Marshall JC, Mazuski JE, McIntyre LA, McLean AS, Mehta S, Moreno RP, Myburgh J, Navalesi P, Nishida O, Osborn TM, Perner A, Plunkett CM, Ranieri M, Schorr CA, Seckel MA, Seymour CW, Shieh L, Shukri KA, Simpson SQ, Singer M, Thompson BT, Townsend SR, Van der Poll T, Vincent JL, Wiersinga WJ, Zimmerman JL, Dellinger RP. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med. 2017 Mar;43(3):304-377. - PubMed
-
- Hamzaoui O, Scheeren TWL, Teboul JL. Norepinephrine in septic shock: when and how much? Curr Opin Crit Care. 2017 Aug;23(4):342-347. - PubMed
-
- Jia L, Wang P, Li C, Xie J. THE EFFICACY AND SAFETY OF VASOPRESSORS FOR SEPTIC SHOCK PATIENTS: A SYSTEMIC REVIEW AND NETWORK META-ANALYSIS. Shock. 2023 Dec 01;60(6):746-752. - PubMed
Publication types
LinkOut - more resources
Full Text Sources