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Ischemic cardiomyopathy (ICM) is a term that refers to the heart's decreased ability to pump blood properly, due to myocardial damage brought upon by ischemia. When discussing the term ICM, coronary artery disease (CAD) has to be addressed. CAD is a condition characterized by the formation of plaques in the coronary blood vessels, decreasing their capacity to supply nutrients and oxygen to the contractile heart muscle. ICM has a spectrum of clinical changes which eventually leads to congestive heart failure (CHF). Initially, there is a reversible loss of cardiac contractile function because of decreased oxygen supply to the heart muscle; however, when there is ischemia for a prolonged period, there is irreversible cardiac muscle damage resulting in cardiac remodeling. Remodeling is primarily achieved by myocardial fibrosis which results in decreased cardiac function, arrhythmia, and possible cardiac conduction system impairment.
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Khan MA, Hashim MJ, Mustafa H, Baniyas MY, Al Suwaidi SKBM, AlKatheeri R, Alblooshi FMK, Almatrooshi MEAH, Alzaabi MEH, Al Darmaki RS, Lootah SNAH. Global Epidemiology of Ischemic Heart Disease: Results from the Global Burden of Disease Study. Cureus. 2020 Jul 23;12(7):e9349.
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Im DJ, Youn JC, Lee HJ, Nam K, Suh YJ, Hong YJ, Hur J, Kim YJ, Choi BW, Kang SM. Role of Cardiac Computed Tomography for Etiology Evaluation of Newly Diagnosed Heart Failure with Reduced Ejection Fraction. J Clin Med. 2020 Jul 17;9(7)
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Gatti M, Carisio A, D'Angelo T, Darvizeh F, Dell'Aversana S, Tore D, Centonze M, Faletti R. Cardiovascular magnetic resonance in myocardial infarction with non-obstructive coronary arteries patients: A review. World J Cardiol. 2020 Jun 26;12(6):248-261.
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Subramanyam P, Palaniswamy SS. Does myocardial viability detection improve using a novel combined 99mTc sestamibi infusion and low dose dobutamine infusion in high risk ischemic cardiomyopathy patients? Anatol J Cardiol. 2020 Aug;24(2):83-91.
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