Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Book

Embryology, Heart

Philip Mathew  1 , Bruno Bordoni  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
Affiliations
Free Books & Documents
Book

Embryology, Heart

Philip Mathew et al.
Free Books & Documents

Excerpt

The first system to develop due to the growing embryo's ever-increasing metabolic demands is the cardiovascular system. Initially, simple diffusion of necessary nutrients is sufficient but eventually becomes inadequate to supply oxygen and nutrients. Cardiac development is a complicated interplay of molecular communication, ensuring the proper formation of structures and spatial configuration changes in the appropriate timing. Interference with this process, whether genetic or environmental, leads to the formation of congenital heart diseases.

PubMed Disclaimer

Conflict of interest statement

Disclosure: Philip Mathew declares no relevant financial relationships with ineligible companies.

Disclosure: Bruno Bordoni declares no relevant financial relationships with ineligible companies.

References

    1. Wu M. Mechanisms of Trabecular Formation and Specification During Cardiogenesis. Pediatr Cardiol. 2018 Aug;39(6):1082-1089. - PMC - PubMed
    1. Mohan RA, Boukens BJ, Christoffels VM. Developmental Origin of the Cardiac Conduction System: Insight from Lineage Tracing. Pediatr Cardiol. 2018 Aug;39(6):1107-1114. - PMC - PubMed
    1. Hu W, Xin Y, Zhao Y, Hu J. Shox2: The Role in Differentiation and Development of Cardiac Conduction System. Tohoku J Exp Med. 2018 Mar;244(3):177-186. - PubMed
    1. MacGrogan D, Münch J, de la Pompa JL. Notch and interacting signalling pathways in cardiac development, disease, and regeneration. Nat Rev Cardiol. 2018 Nov;15(11):685-704. - PubMed
    1. Luxán G, D’Amato G, de la Pompa JL. Intercellular Signaling in Cardiac Development and Disease: The NOTCH pathway. In: Nakanishi T, Markwald RR, Baldwin HS, Keller BB, Srivastava D, Yamagishi H, editors. Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology [Internet] Springer; Tokyo: 2016. Jun 25, pp. 103–114. - PubMed

Publication types

LinkOut - more resources