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Book

Biochemistry, Lipase

Yasaman Pirahanchi  1 , Sandeep Sharma  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Biochemistry, Lipase

Yasaman Pirahanchi et al.
Free Books & Documents

Excerpt

Lipases are a family of enzymes that break down triglycerides into free fatty acids and glycerol. There are expressed and active in multiple tissues; for example, hepatic lipases are in the liver, hormone-sensitive lipases are in adipocytes, lipoprotein lipase is in the vascular endothelial surface, and pancreatic lipase is in the small intestine. Lipases in pancreatic secretions are responsible for digestion and hydrolysis of fat and absorption of fat-soluble vitamins. Understanding the lipase function is crucial for the pathophysiology of fat necrosis and acute and chronic pancreatitis. Also, lipases play an essential role in the mechanism of some cholesterol-lowering medications. This review will explore the lipase enzyme's function, pathophysiology, and clinical significance.

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Conflict of interest statement

Disclosure: Yasaman Pirahanchi declares no relevant financial relationships with ineligible companies.

Disclosure: Sandeep Sharma declares no relevant financial relationships with ineligible companies.

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References

    1. Holmes RS, Cox LA, VandeBerg JL. Comparative studies of mammalian acid lipases: Evidence for a new gene family in mouse and rat (Lipo). Comp Biochem Physiol Part D Genomics Proteomics. 2010 Sep;5(3):217-26. - PMC - PubMed
    1. Cerk IK, Wechselberger L, Oberer M. Adipose Triglyceride Lipase Regulation: An Overview. Curr Protein Pept Sci. 2018;19(2):221-233. - PMC - PubMed
    1. Lenfant N, Hotelier T, Velluet E, Bourne Y, Marchot P, Chatonnet A. ESTHER, the database of the α/β-hydrolase fold superfamily of proteins: tools to explore diversity of functions. Nucleic Acids Res. 2013 Jan;41(Database issue):D423-9. - PMC - PubMed
    1. Holmquist M. Alpha/Beta-hydrolase fold enzymes: structures, functions and mechanisms. Curr Protein Pept Sci. 2000 Sep;1(2):209-35. - PubMed
    1. Salah RB, Mosbah H, Fendri A, Gargouri A, Gargouri Y, Mejdoub H. Biochemical and molecular characterization of a lipase produced by Rhizopus oryzae. FEMS Microbiol Lett. 2006 Jul;260(2):241-8. - PubMed

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