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. 2019 Feb 5;27(2):209-210.
doi: 10.1016/j.str.2019.01.007.

How Natural Killer Cell Receptors Stick to Cell-Cell Adhesion Proteins

Sharanbasappa S Karade  1 , Roy A Mariuzza  2
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How Natural Killer Cell Receptors Stick to Cell-Cell Adhesion Proteins

Sharanbasappa S Karade et al. Structure. .
Free article

Abstract

The cytolytic activity of NK cells is regulated by activating and inhibitory receptors, including ones that recognize cell-cell adhesion molecules. In this issue of Structure, Deuss et al. (2019) report the structure of nectin-like protein-5 bound to the NK inhibitory receptor CD96, a promising new target for cancer immunotherapy.

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