Death Eaters Rely on Metabolic Signaling to Wield Anti-inflammatory Responses
- PMID: 30726754
- DOI: 10.1016/j.cmet.2019.01.010
Death Eaters Rely on Metabolic Signaling to Wield Anti-inflammatory Responses
Abstract
Efferocytosis, the process by which dying or dead cells are removed by phagocytes, is essential to tissue homeostasis. However, how these "death eaters" or efferocytes coordinate phagocytosis with their immune function is incompletely understood. In this issue, Zhang et al. (2018) reveal how metabolic signaling drives the anti-inflammatory responses of efferocytes to promote wound healing.
Crown Copyright © 2019. Published by Elsevier Inc. All rights reserved.
Comment on
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Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair.Cell Metab. 2019 Feb 5;29(2):443-456.e5. doi: 10.1016/j.cmet.2018.12.004. Epub 2018 Dec 27. Cell Metab. 2019. PMID: 30595481 Free PMC article.
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