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Meta-Analysis
. 2019 Feb 6;17(1):18.
doi: 10.1186/s12958-019-0460-4.

The role of recombinant LH in women with hypo-response to controlled ovarian stimulation: a systematic review and meta-analysis

Alessandro Conforti  1 , Sandro C Esteves  2 , Francesca Di Rella  3 , Ida Strina  4 , Pasquale De Rosa  4 , Alessia Fiorenza  5 , Fulvio Zullo  4 , Giuseppe De Placido  4 , Carlo Alviggi  4   6
Affiliations
Meta-Analysis

The role of recombinant LH in women with hypo-response to controlled ovarian stimulation: a systematic review and meta-analysis

Alessandro Conforti et al. Reprod Biol Endocrinol. .

Erratum in

Abstract

Objective: To study the role of recombinant human LH supplementation in women with hypo-response to ovarian stimulation.

Methods: We performed a systematic review and meta-analysis of prospective clinical trials in which recombinant FSH monotherapy protocols were compared with LH-supplemented protocols in hypo-responders. A search was conducted of the Scopus, MEDLINE databases without time or language restrictions. Primary outcome was clinical pregnancy rate.

Results: Significantly higher clinical pregnancy rates (odds ratio: 2.03, P = 0.003), implantation rates (odds ratio: 2.62, P = 0.004) and number of oocytes retrieved (weight mean differences: 1.98, P = 0.03) were observed in hypo-responders supplemented with recombinant LH versus hypo-responders who underwent FSH monotherapy. No differences in terms of mature oocytes or miscarriage rates were found between the two groups.

Conclusion: In conclusion, our analysis confirms that women with a hypo-response to exogenous gonadotropins might benefit from LH supplementation. However, more trials are required before a definitive conclusion can be drawn.

Keywords: Assisted reproductive technologies; Hypo-responders; In vitro fertilization; LH; Ovulation induction; Recombinant LH.

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Conflict of interest statement

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

Prof Alviggi reports personal fees and honoraria from Merck outside the submitted work. Prof. Esteves declares receipt of speaker’s fees from Merck, Lilly, and Besins outside the present study. Dr. Conforti, Dr. Di Rella Dr. Strina, Dr. De Rosa, Dr. Fiorenza, Prof Zullo and Prof. De Placido have nothing to disclose.

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Study flow chart according to PRISMA guidelines
Fig. 2
Fig. 2
Forest plot of odds ratio for the clinical pregnancy rate in rFSH + rLH versus rFSH alone treatment
Fig. 3
Fig. 3
Forest plot of weight mean difference for the number of oocytes retrieved in rFSH + rLH versus rFSH alone treatment
Fig. 4
Fig. 4
Forest plot of odds ratio for implantation rate in rFSH + rLH versus rFSH alone treatment
See this image and copyright information in PMC

References

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