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Editorial
. 2019 Feb 6;11(4):1075-1076.
doi: 10.18632/aging.101817.

New avenues in cardio-oncology

Valentina Sala  1 , Mingchuan Li  1 , Alessandra Ghigo  1
Affiliations
Editorial

New avenues in cardio-oncology

Valentina Sala et al. Aging (Albany NY). .
No abstract available

Keywords: PI3Kγ; TLR9; anthracycline cardiotoxicity; autophagy; mitochondrial DNA.

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Figures

Figure 1
Figure 1
Dual action of PI3Kγ inhibitors in AIC. PI3Kγ inhibition protects against anthracycline-induced cardiotoxicity by boosting autophagic clearance of damaged mitochondria and preventing a maladaptive metabolic rewiring of cardiomyocytes. Furthermore, PI3Kγ blockade synergizes with the anticancer action of anthracyclines, and delays tumor growth by activating specific subsets of tumor-associated macrophages. Overall, PI3Kγ inhibitors may be the stone to simultaneously kill the two angry birds of cardiotoxicity and cancer.
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