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. 2019 Feb 6;101(3):353-355.
doi: 10.1016/j.neuron.2019.01.034.

Substance P and Inflammatory Pain: Getting It Wrong and Right Simultaneously

Edita Navratilova  1 , Frank Porreca  2
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Substance P and Inflammatory Pain: Getting It Wrong and Right Simultaneously

Edita Navratilova et al. Neuron. .
Free article

Abstract

How do neuropeptides participate in the classic neuroinflammatory sequelae of tissue injury that includes pain, immune cell infiltration, and swelling? In this issue of Neuron, Green et al. (2019) reveal that MrgprB2/MrgprX2 is a mast cell substance-P-specific receptor that critically links neural and immune systems and offers new approaches for neuroinflammatory therapeutics.

Keywords: MrgprB2 receptor; NK1 receptor; mast cells; neuroinflammation; pain; substance P.

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