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doi: 10.1016/j.neuron.2019.01.034.
Substance P and Inflammatory Pain: Getting It Wrong and Right Simultaneously
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- PMID: 30731054
- DOI: 10.1016/j.neuron.2019.01.034
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Substance P and Inflammatory Pain: Getting It Wrong and Right Simultaneously
Neuron.
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Free article
Abstract
How do neuropeptides participate in the classic neuroinflammatory sequelae of tissue injury that includes pain, immune cell infiltration, and swelling? In this issue of Neuron, Green et al. (2019) reveal that MrgprB2/MrgprX2 is a mast cell substance-P-specific receptor that critically links neural and immune systems and offers new approaches for neuroinflammatory therapeutics.
Keywords: MrgprB2 receptor; NK1 receptor; mast cells; neuroinflammation; pain; substance P.
Copyright © 2019 Elsevier Inc. All rights reserved.
Comment on
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A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain.Neuron. 2019 Feb 6;101(3):412-420.e3. doi: 10.1016/j.neuron.2019.01.012. Epub 2019 Jan 24. Neuron. 2019. PMID: 30686732 Free PMC article.
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