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Observational Study
. 2019 Feb;98(6):e14486.
doi: 10.1097/MD.0000000000014486.

Prognostic value of serum albumin for patients with acute aortic dissection: A retrospective cohort study

Yongli Gao  1   2 , Dongze Li  1   2 , Yu Cao  1   2 , Xingyu Zhu  1   2 , Zhi Zeng  1   2 , Li Tang  3
Affiliations
Observational Study

Prognostic value of serum albumin for patients with acute aortic dissection: A retrospective cohort study

Yongli Gao et al. Medicine (Baltimore). 2019 Feb.

Abstract

Serum albumin (SA) is associated with inflammation and thrombosis, which are involved in acute aortic dissection (AAD). Our aim was to investigate the effect of SA level on survival in patients with AAD.We analyzed 777 patients with AAD. The patients were divided into hypoalbuminemia and non-hypoalbuminemia groups according to their AAD Stanford classification. Multivariable Cox regression was used to investigate the association between SA levels and in-hospital mortality in type A and B AAD.A total of 103 (13.3%) patients died in-hospital. The in-hospital mortality in type A and B patients with hypoalbuminemia was higher compared to those without (type A: 34.2% vs 13.9%, P <.001; type B: 7.9% vs 1.6%, P = .001). Kaplan-Meier analysis showed that survival was significantly lower in patients with hypoalbuminemia compared to those without, regardless of AAD type (type A: log-rank χ = 14.71; P <.001; Type B: log-rank χ = 10.42; P = .001). After adjusting for confounding factors, hypoalbuminemia was an independent predictor of in-hospital mortality in patients with either type A (HR, 2.492; 95% confidence interval [CI], 1.247-4.979; P = .010) or type B (HR, 8.729; 95% CI, 1.825-41.736; P = .007).SA is independently associated with increased in-hospital mortality in both type A and B AAD.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
(A) The in-hospital mortality in different levels of serum albumin in type A acute aortic dissection; (B) Kaplan–Meier analysis survival curve according to different levels of serum albumin in all patients with type A acute aortic dissection; (C) Kaplan–Meier analysis survival curve according to levels of serum albumin in patients with type A acute aortic dissection receiving medication only; (D) Kaplan–Meier analysis survival curve according to levels of serum albumin in patients with type A acute aortic dissection receiving surgery.
Figure 2
Figure 2
(A) The in-hospital mortality in different levels of serum albumin in type B acute aortic dissection; (B) Kaplan–Meier analysis survival curve according to different levels of serum albumin in all patients with type B acute aortic dissection; (C) Kaplan–Meier analysis survival curve according to different levels of serum albumin in patients with type B acute aortic dissection receiving medication therapy; (D) Kaplan–Meier analysis survival curve according to different levels of serum albumin in patients with type B acute aortic dissection receiving endovascular therapy.
See this image and copyright information in PMC

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