Silent Intracerebral Hemorrhage in Patients Randomized to Stenting or Endarterectomy for Symptomatic Carotid Stenosis

Mandy D Müller¹, Lisa M Jongen², Aysun Altinbas³, Kristine A Blackham⁴, Paul J Nederkoorn⁵, Sumaira Macdonald⁶, Rolf Jäger⁷, Thomas Wolff⁸, Philippe A Lyrer¹, L Jaap Kappelle⁹, Stephan G Wetzel¹⁰, Toby Richards¹¹, Jeroen Hendrikse², Gert J de Borst¹², H Bart van der Worp⁹, Stefan T Engelter^{1

13}, David J Werring¹⁴, Martin M Brown¹⁴, Leo H Bonati^{1

14}; ICSS-MRI Study Investigators¹

Affiliations

¹ Department of Neurology and Stroke Center, University Hospital Basel, University of Basel, Basel, Switzerland.
² Department of Radiology, University Medical Center Utrecht, University The Netherlands, Utrecht, the Netherlands.
³ Department of Pediatric Neurology, Leiden University Medical Center, Leiden University, Leiden, the Netherlands.
⁴ Department of Diagnostic and Interventional Neuroradiology, University Hospital Basel, University of Basel, Basel, Switzerland.
⁵ Department of Neurology, Academic Medical Center, Amsterdam, the Netherlands.
⁶ Department of Radiology, Freeman Hospital, Newcastle upon Tyne, UK.
⁷ Academic Neuroradiological Unit, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, UK.
⁸ Department of Vascular Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.
⁹ Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
¹⁰ Institute of Neuroradiology, Clinic Hirslanden, Zurich, Switzerland.
¹¹ Division of Surgery and Interventional Sciences, University College London, London, UK.
¹² Department of Vascular Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
¹³ Neurorehabilitation Unit, University Center for Medicine of Aging and Rehabilitation Basel, Felix Platter Hospital, University of Basel, Basel, Switzerland.
¹⁴ Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, UK.

PMID: 30732448
PMCID: PMC6372891
DOI: 10.5853/jos.2018.02838

Silent Intracerebral Hemorrhage in Patients Randomized to Stenting or Endarterectomy for Symptomatic Carotid Stenosis

Mandy D Müller et al. J Stroke. 2019 Jan.

. 2019 Jan;21(1):116-119.

doi: 10.5853/jos.2018.02838. Epub 2019 Jan 31.

Authors

Affiliations

¹ Department of Neurology and Stroke Center, University Hospital Basel, University of Basel, Basel, Switzerland.
² Department of Radiology, University Medical Center Utrecht, University The Netherlands, Utrecht, the Netherlands.
³ Department of Pediatric Neurology, Leiden University Medical Center, Leiden University, Leiden, the Netherlands.
⁴ Department of Diagnostic and Interventional Neuroradiology, University Hospital Basel, University of Basel, Basel, Switzerland.
⁵ Department of Neurology, Academic Medical Center, Amsterdam, the Netherlands.
⁶ Department of Radiology, Freeman Hospital, Newcastle upon Tyne, UK.
⁷ Academic Neuroradiological Unit, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, UK.
⁸ Department of Vascular Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.
⁹ Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
¹⁰ Institute of Neuroradiology, Clinic Hirslanden, Zurich, Switzerland.
¹¹ Division of Surgery and Interventional Sciences, University College London, London, UK.
¹² Department of Vascular Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
¹³ Neurorehabilitation Unit, University Center for Medicine of Aging and Rehabilitation Basel, Felix Platter Hospital, University of Basel, Basel, Switzerland.
¹⁴ Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, UK.

PMID: 30732448
PMCID: PMC6372891
DOI: 10.5853/jos.2018.02838

No abstract available

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Figures

**Figure 1.**
Study flow chart. Inclusion and reasons for exclusion of patients from analysis. CAS, carotid artery stenting; CEA, carotid endarterectomy; BMT, best medical therapy; MRI, magnetic resonance imaging; GRE, gradient-recalled echo; MI, myocardial infarction.

See this image and copyright information in PMC

References

1. Bonati LH, Jongen LM, Haller S, Flach HZ, Dobson J, Nederkoorn PJ, et al. New ischaemic brain lesions on MRI after stenting or endarterectomy for symptomatic carotid stenosis: a substudy of the international carotid stenting study (ICSS) Lancet Neurol. 2010;9:353–362. - PubMed
1. International Carotid Stenting Study investigators. Ederle J, Dobson J, Featherstone RL, Bonati LH, van der Worp HB, et al. Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (international carotid stenting study): an interim analysis of a randomised controlled trial. Lancet. 2010;375:985–997. - PMC - PubMed
1. Gregoire SM, Chaudhary UJ, Brown MM, Yousry TA, Kallis C, Jäger HR, et al. The Microbleed Anatomical Rating Scale (MARS): reliability of a tool to map brain microbleeds. Neurology. 2009;73:1759–1766. - PubMed

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Silent Intracerebral Hemorrhage in Patients Randomized to Stenting or Endarterectomy for Symptomatic Carotid Stenosis

Affiliations

Silent Intracerebral Hemorrhage in Patients Randomized to Stenting or Endarterectomy for Symptomatic Carotid Stenosis

Authors

Affiliations

Figures

References

Grants and funding

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