Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Feb 7;19(Suppl 2):27.
doi: 10.1186/s12872-019-1000-z.

Proceedings of the 3rd annual Acute Cardiac Unloading and REcovery (A-CURE) symposium

Uma Chandrasekaran  1 , Daniel Burkhoff  2 , Kiyotake Ishikawa  3 , Lija Swain  4 , Kenji Sunagawa  5 , Jacob Møller  6 , Carlos Santos-Gallego  3 , Shiva Annamalai  4 , James Udelson  4 , Ralf Westenfeld  7 , Navin Kapur  4 , Xiaoying Qiao  4 , Julian Wiora  7 , Andreas Schäfer  8 , Alexander Bernhardt  9 , Ajar Kochar  10 , Robert Kloner  11 , Haroon Faraz  12
Affiliations

Proceedings of the 3rd annual Acute Cardiac Unloading and REcovery (A-CURE) symposium

Uma Chandrasekaran et al. BMC Cardiovasc Disord. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

Not Applicable.

Consent for publication

Informed consent to publish had been obtained from the patients featured in the “First In Man Implantations of a Newly Designed Transaortic Axial Flow Ventricular Assist Device, Impella 5.5” and “Case Report from the Door to Unload in STEMI Trial”presentations.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Definition of myocardial unloading and benefits during myocardial infarction. LV = left ventricular; PCWP = pulmonary capillary wedge pressure; CBF = coronary blood flow
Fig. 2
Fig. 2
Effect of MCS Devices on PVA and LVEDP in an Animal Model of Profound Cardiogenic Shock. CS = cardiogenic shock; MCS = mechanical circulatory support; PVA = pressure-volume area; LVEDP = left ventricular end-diastolic pressure; VA-ECMO = veno-arterial extracorporeal membrane oxygenation
Fig. 3
Fig. 3
LV Unloading With Impella During HF Reduces Myocardial Glucose Consumption and Lactate Production in an Animal Model. MI = myocardial infarction; IMP = Impella
Fig. 4
Fig. 4
LV Unloading With Impella for 30 min Increases Microcirculatory Flow to the Area at Risk. CFI = collateral flow index; VA-ECMO = veno-arterial extracorporeal membrane oxygenation
Fig. 5
Fig. 5
Lower Incidence of CI-AKI During HR-PCI with Impella support versus VA-ECMO. CI-AKI = contrast induced acute kidney injury; HR-PCI = high risk percutaneous coronary intervention, VA-ECMO = veno-arterial extracorporeal membrane oxygenation
Fig. 6
Fig. 6
Reduced Incidence of Contrast-Induced Nephropathy with Impella Support during HR-PCI. CIN = Contrast-Induced Nephropathy
Fig. 7
Fig. 7
Summary of Features of Impella 5.5 and Impella 5.0 Heart Pumps
Fig. 8
Fig. 8
Long-term Mortality Stratified by Heart Failure Status
Fig. 9
Fig. 9
Study Design of the Door-To-Unload in STEMI Pilot Trial. U-DR = delayed reperfusion after 30 min of LV unloading by the Impella CP; U-IR = immediate reperfusion after placement of the Impella CP; CP = cardiac power
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Uriel N, Sayer G, Annamalai S, et al. Mechanical unloading in heart failure. J Am Coll Cardiol. 2018;72(5):569–580. doi: 10.1016/j.jacc.2018.05.038. - DOI - PubMed
    1. Pfeffer JM, Pfeffer MA, Braunwald E. Influence of chronic captopril therapy on the infarcted left ventricle of the rat. Circ Res. 1985;57:84–95. doi: 10.1161/01.RES.57.1.84. - DOI - PubMed
    1. Pfeffer MA, Lamas GA, Vaughan DE, et al. Effect of captopril on progressive ventricular dilatation after anterior myocardial infarction. N Engl J Med. 1988;319:80–86. doi: 10.1056/NEJM198807143190204. - DOI - PubMed
    1. Smalling RW, Cassidy DB, Barrett R, et al. Improved regional myocardial blood flow, left ventricular unloading, and infarct salvage using an axial-flow, transvalvular left ventricular assist device. A comparison with intra-aortic balloon counterpulsation and reperfusion alone in a canine infarction model. Circulation. 1992;85(3):1152–1159. doi: 10.1161/01.CIR.85.3.1152. - DOI - PubMed
    1. Meyns B, Stolinski J, Leunens V, et al. Left ventricular support by catheter-mounted axial flow pump reduces infarct size. J Am Coll Cardiol. 2003;41:1087–1095. doi: 10.1016/S0735-1097(03)00084-6. - DOI - PubMed

Publication types