Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Feb 8;363(6427):582-583.
doi: 10.1126/science.aav0558.

Branched-chain amino acids in disease

Phillip J White  1 , Christopher B Newgard  2
Affiliations

Branched-chain amino acids in disease

Phillip J White et al. Science. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.. BCAAs: Biomarkers and causal agents of cardiometabolic disease
Diet, obesity, the gut microbiota, and genetics can increase circulating BCAAs. BCAAs are proposed to promote increased hepatic lipid storage, cardiac hypertrophy, and lipid accumulation contributing to muscle insulin resistance.
See this image and copyright information in PMC

References

    1. Newgard CB. 2017. Metabolomics and metabolic diseases: where do we stand? Cell Metabolism 25: 43–56. - PMC - PubMed
    1. Felig P, Marliss E, Cahill GF. 1969. Plasma amino acid levels and insulin secretion in obesity. New Engl J Med. 281:811–816. - PubMed
    1. Newgard CB, An J. Bain JR, Muehlbauer MJ, Stevens RD, Lien LF, et al. 2009. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab. 9:311–326. - PMC - PubMed
    1. Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, McCabe E, et al. 2011. Metabolic profiles and the risk of developing diabetes. Nat Med. 17:448–453. - PMC - PubMed
    1. She P, Van Horn C, Reid T, Hutson SM, Cooney RN, and Lynch CJ 2007. Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism. Am. J. Physiol. Endocrinol. Metab. 293, E1552–63. - PMC - PubMed

Publication types

Substances