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. 2019 Feb;80(1):46-50.
doi: 10.1055/s-0038-1666851. Epub 2018 Jul 6.

Revascularization of AlloDerm Used during Endoscopic Skull Base Surgery

Zahrah M Taufique  1 , Nupur Bhatt  1 , David Zagzag  2 , Richard A Lebowitz  1 , Seth M Lieberman  1
Affiliations

Revascularization of AlloDerm Used during Endoscopic Skull Base Surgery

Zahrah M Taufique et al. J Neurol Surg B Skull Base. 2019 Feb.

Abstract

Objectives AlloDerm is an acellular dermal matrix often used for reconstruction throughout the body. AlloDerm has been shown to undergo revascularization when used to reconstruct soft tissue such as in abdominal wall reconstruction. In this study, the authors review the literature on revascularization of AlloDerm and demonstrate the histologic findings of AlloDerm after implantation during skull base reconstruction. Study Design Literature review and case reports. Setting Tertiary Care Institution Participants Patients from a tertiary care institution Main Outcome Measures Histologic slides are evaluated and compared with nonimplanted AlloDerm. Methods The authors review a case of explanted AlloDerm that had been used for skull base reconstruction after endoscopic skull base surgery. Results Upon reviewing the histologic slides of explanted AlloDerm to nonimplanted AlloDerm, we demonstrate revascularization of AlloDerm when used in skull base reconstruction. Representative slides will be included. Conclusions AlloDerm undergoes revascularization when used for skull base reconstruction.

Keywords: AlloDerm; acellular dermal matrix; revascularization; skull base reconstruction; skull base surgery.

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Conflict of interest statement

Conflict of Interest None.

Figures

Fig. 1
Fig. 1
The image showing newly formed vascular channels (arrows) within the AlloDerm. Rare hemosiderin-laden macrophages are also present (arrowheads). In addition, spindle cells consistent with organization are noted (stars) (hematoxylin and eosin stain, x200).
Fig. 2
Fig. 2
( A , C ) The image showing newly formed vascular channels (arrows) and a mixed cellular infiltrate (stars) within the AlloDerm. ( B , D ) CD34 immunostains highlight the newly formed vascular channels (immunoperoxidase, B X50; D X200).
Fig. 3
Fig. 3
The image showing nonimplanted acellular AlloDerm.
See this image and copyright information in PMC

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