Advancing Frontiers in Bone Bioprinting

Nureddin Ashammakhi^{1

2

3

4}, Anwarul Hasan^{5

6}, Outi Kaarela⁴, Batzaya Byambaa^{7

8}, Amir Sheikhi¹, Akhilesh K Gaharwar⁹, Ali Khademhosseini^{1

2

3}

Affiliations

¹ Center for Minimally Invasive Therapeutics (C-MIT), University of California - Los Angeles, Los Angeles, CA, 90095, USA.
² California NanoSystems Institute (CNSI), University of California - Los Angeles, Los Angeles, CA, 90095, USA.
³ Department of Bioengineering, University of California - Los Angeles, Los Angeles, CA, 90095, USA.
⁴ Division of Plastic Surgery, Department of Surgery, Oulu Univesity Hospital, Oulu, FI-90014, Finland.
⁵ Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, Doha, 2713, Qatar.
⁶ Biomedical Research Center, Qatar University, Doha, 2713, Qatar.
⁷ Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02115, USA.
⁸ Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
⁹ Department of Biomedical Engineering, Department of Materials Science and Engineering, and Center for Remote Health and Technologies, Texas A&M University, College Station, TX, 77841, USA.

PMID: 30734530
DOI: 10.1002/adhm.201801048

Review

Advancing Frontiers in Bone Bioprinting

Nureddin Ashammakhi et al. Adv Healthc Mater. 2019 Apr.

. 2019 Apr;8(7):e1801048.

doi: 10.1002/adhm.201801048. Epub 2019 Feb 8.

Authors

Nureddin Ashammakhi^{1

2

3

4}, Anwarul Hasan^{5

6}, Outi Kaarela⁴, Batzaya Byambaa^{7

8}, Amir Sheikhi¹, Akhilesh K Gaharwar⁹, Ali Khademhosseini^{1

2

3}

Affiliations

¹ Center for Minimally Invasive Therapeutics (C-MIT), University of California - Los Angeles, Los Angeles, CA, 90095, USA.
² California NanoSystems Institute (CNSI), University of California - Los Angeles, Los Angeles, CA, 90095, USA.
³ Department of Bioengineering, University of California - Los Angeles, Los Angeles, CA, 90095, USA.
⁴ Division of Plastic Surgery, Department of Surgery, Oulu Univesity Hospital, Oulu, FI-90014, Finland.
⁵ Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, Doha, 2713, Qatar.
⁶ Biomedical Research Center, Qatar University, Doha, 2713, Qatar.
⁷ Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02115, USA.
⁸ Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
⁹ Department of Biomedical Engineering, Department of Materials Science and Engineering, and Center for Remote Health and Technologies, Texas A&M University, College Station, TX, 77841, USA.

PMID: 30734530
DOI: 10.1002/adhm.201801048

Abstract

Three-dimensional (3D) bioprinting of cell-laden biomaterials is used to fabricate constructs that can mimic the structure of native tissues. The main techniques used for 3D bioprinting include microextrusion, inkjet, and laser-assisted bioprinting. Bioinks used for bone bioprinting include hydrogels loaded with bioactive ceramics, cells, and growth factors. In this review, a critical overview of the recent literature on various types of bioinks used for bone bioprinting is presented. Major challenges, such as the vascularity, clinically relevant size, and mechanical properties of 3D printed structures, that need to be addressed to successfully use the technology in clinical settings, are discussed. Emerging approaches to solve these problems are reviewed, and future strategies to design customized 3D printed structures are proposed.

Keywords: 3D bioprinting; bioinks; bone defects; tissue engineering.

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Advancing Frontiers in Bone Bioprinting

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