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Comment
. 2019 Feb 7;176(4):681-684.
doi: 10.1016/j.cell.2019.01.027.

Replication Timing Becomes Intertwined with 3D Genome Organization

Jian Ma  1 , Zhijun Duan  2
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Comment

Replication Timing Becomes Intertwined with 3D Genome Organization

Jian Ma et al. Cell. .
Free article

Abstract

Through dissecting the link between spatial genome organization and DNA replication timing, Sima et al. (2018) discover early replicating control elements (ERCEs), a new type of cis-acting elements that regulate replication timing, transcription, and multiple layers of three-dimensional features of genome organization. The study has important implications for unraveling control elements of high-order genome structure and function.

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  • Identifying cis Elements for Spatiotemporal Control of Mammalian DNA Replication.
    Sima J, Chakraborty A, Dileep V, Michalski M, Klein KN, Holcomb NP, Turner JL, Paulsen MT, Rivera-Mulia JC, Trevilla-Garcia C, Bartlett DA, Zhao PA, Washburn BK, Nora EP, Kraft K, Mundlos S, Bruneau BG, Ljungman M, Fraser P, Ay F, Gilbert DM. Sima J, et al. Cell. 2019 Feb 7;176(4):816-830.e18. doi: 10.1016/j.cell.2018.11.036. Epub 2018 Dec 27. Cell. 2019. PMID: 30595451 Free PMC article.

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