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. 2019 Feb 7;176(4):684-685.
doi: 10.1016/j.cell.2019.01.028.

Designer Assays for Your Sick, Subdivided Heart

Kevin Kit Parker  1
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Designer Assays for Your Sick, Subdivided Heart

Kevin Kit Parker. Cell. .
Free article

Abstract

Using induced pluripotent stem cells and microelectromechanical device technology Zhao et al. have developed 'organs on chips' representing the different chambers of the heart and used them to replicate healthy and diseased tissues in vitro. These systems offer investigators and the pharmaceutical industry a new tool in testing the safety and efficacy of new medicinal therapeutics.

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  • A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling.
    Zhao Y, Rafatian N, Feric NT, Cox BJ, Aschar-Sobbi R, Wang EY, Aggarwal P, Zhang B, Conant G, Ronaldson-Bouchard K, Pahnke A, Protze S, Lee JH, Davenport Huyer L, Jekic D, Wickeler A, Naguib HE, Keller GM, Vunjak-Novakovic G, Broeckel U, Backx PH, Radisic M. Zhao Y, et al. Cell. 2019 Feb 7;176(4):913-927.e18. doi: 10.1016/j.cell.2018.11.042. Epub 2019 Jan 24. Cell. 2019. PMID: 30686581 Free PMC article.

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