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Comment
. 2019 Feb 7;24(2):199-200.
doi: 10.1016/j.stem.2019.01.007.

Lysosomes Dare Cells to be Different(iated)

Agnes Roczniak-Ferguson  1 , Shawn M Ferguson  2
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Lysosomes Dare Cells to be Different(iated)

Agnes Roczniak-Ferguson et al. Cell Stem Cell. .
Free article

Abstract

In this issue of Cell Stem Cell, Villegas et al. (2019) used a genome-wide CRISPR screen to identify ESC pluripotency regulators, which generated insights into how signaling from lysosome enables cells to transcriptionally regulate their metabolism. Further investigation of human genetics identified a human developmental disease arising from a defect in this process.

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  • Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3.
    Villegas F, Lehalle D, Mayer D, Rittirsch M, Stadler MB, Zinner M, Olivieri D, Vabres P, Duplomb-Jego L, De Bont ESJM, Duffourd Y, Duijkers F, Avila M, Geneviève D, Houcinat N, Jouan T, Kuentz P, Lichtenbelt KD, Thauvin-Robinet C, St-Onge J, Thevenon J, van Gassen KLI, van Haelst M, van Koningsbruggen S, Hess D, Smallwood SA, Rivière JB, Faivre L, Betschinger J. Villegas F, et al. Cell Stem Cell. 2019 Feb 7;24(2):257-270.e8. doi: 10.1016/j.stem.2018.11.021. Epub 2018 Dec 27. Cell Stem Cell. 2019. PMID: 30595499

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