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. 2019 Feb 6;17(2):100.
doi: 10.3390/md17020100.

New Acyclic Cytotoxic Jasplakinolide Derivative from the Marine Sponge Jaspis splendens

Sherif S Ebada  1   2   3 , Werner E G Müller  4 , Wenhan Lin  5 , Peter Proksch  6
Affiliations

New Acyclic Cytotoxic Jasplakinolide Derivative from the Marine Sponge Jaspis splendens

Sherif S Ebada et al. Mar Drugs. .

Abstract

A new acylic jasplakinolide congener (2), another acyclic derivative requiring revision (4), together with two jasplakinolide derivatives including the parent compound jasplakinolide (1) were isolated from the Indonesian marine sponge Jaspis splendens. The chemical structures of the new and known compounds were unambiguously elucidated based on HRESIMS and exhaustive 1D and 2D NMR spectral analysis as well as a comparison of their NMR data with those of jasplakinolide (1). The isolated jasplakinolides inhibited the growth of mouse lymphoma (L5178Y) cells in vitro with IC50 values in the low micromolar to nanomolar range.

Keywords: Jaspis splendens; cytotoxic activity; jasplakinolide Z5; jasplakinolide Z6.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Structures of 1–5.
Figure 2
Figure 2
1H NMR spectra of 1 and 2 showing differences in aromatic protons at the β-tyrosine residue.
Figure 3
Figure 3
Key 1H–1H COSY, HMBC and ROESY correlations of 2.
Figure 4
Figure 4
Key 1H–1H COSY and HMBC correlations of the tyrosine oxygenated moiety of 4.
See this image and copyright information in PMC

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