Signaling dynamics of DNA damage response invoked by combination therapy are dose-dependent
- PMID: 30737318
- PMCID: PMC6369282
- DOI: 10.1074/jbc.L119.007381
Signaling dynamics of DNA damage response invoked by combination therapy are dose-dependent
Conflict of interest statement
The author declares that he has no conflicts of interest with the contents of this article.
Comment in
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Reply to Koh: Signaling dynamics of DNA damage response invoked by combination therapy are dose-dependent.J Biol Chem. 2019 Feb 8;294(6):2192. doi: 10.1074/jbc.RL119.007419. J Biol Chem. 2019. PMID: 30737319 Free PMC article. No abstract available.
Comment on
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Inhibition of checkpoint kinase 1 following gemcitabine-mediated S phase arrest results in CDC7- and CDK2-dependent replication catastrophe.J Biol Chem. 2019 Feb 8;294(6):1763-1778. doi: 10.1074/jbc.RA118.005231. Epub 2018 Dec 20. J Biol Chem. 2019. PMID: 30573684 Free PMC article.
References
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- Plunkett W., Huang P., Xu Y. Z., Heinemann V., Grunewald R., and Gandhi V. (1995) Gemcitabine: metabolism, mechanisms of action, and self-potentiation. Semin. Oncol. 22, 3–10 - PubMed
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- Koh S.-B., Wallez Y., Dunlop C. R., Bernaldo de Quirós Fernández S., Bapiro T. E., Richards F. M., and Jodrell D. I. (2018) Mechanistic distinctions between CHK1 and WEE1 inhibition guide the scheduling of triple therapy with gemcitabine. Cancer Res. 78, 3054–3066 10.1158/0008-5472.CAN-17-3932 - DOI - PMC - PubMed
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